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The Buzz of Biostimulation


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Biostimulators have been a new innovation that have had the aesthetic industry talking since early 2022. They have emerged as a promising option to restore youthfulness and vitality to the skin. The beauty of biostimulators is that they stimulate the bodies natural regenerative process resulting in plumper, firmer more youthful skin.


What are Biostimulators and why are they being used in the field of aesthetic medicine?


Biostimulators stimulate the body’s cells to function optimally by regenerating tissues. Collagen is a protein that provides structural support for the skin, giving the skin elasticity and tonicity. This gradually declines with age leading to wrinkles and loss of volume. Biostimulators stimulate the production of collagen in the dermis of the skin.


The unique thing about Biostimulators is that they rejuvenate the skin from inwards and may  reduce pigment and stimulate the production of hyaluronic acid that naturally occurs in the dermis that will improve the cellular functioning of the skin.


Biostimulators are like internal care for the epidermis and keep ageing at bay.


What are Biostimulators made up of?


There are a variety of different types of Bio stimulators that are currently used in aesthetic treatments but the most  common  used in injectables contain calcium hydroxyapatite (CaHa), poly-L- Lactic acid (PLLA), or polycaprolatone (PCL). There is also a  new hybrid dermal filler injectable on the market that contains  a combination of hyaluronic acid (HA) and CaHa.


The substances are injected into the skin and the tissues which stimulates regeneration of the epidermis.


Why are these Injectables different?


Injectables  containing CaHa, PLLA and PCL are more permanent in the skin than a hyaluronic acid dermal filer.


CaHa and PLLA slowly degrades but effect can be seen up to 18 months after the treatment. These injectables can be topped up to continue the benefits.


Platelet -rich plasma (PRP) can also be a very powerful stimulator for the functioning of the skin for regeneration,  yielding very natural stimulation and results.



Image from Shutterstock

What’s new


New in the bio stimulating injectable industry are the use of bioactive peptides, polynucleotides and exosomes.


Bioactive peptides, have become an important collection of bio available cosmeceutical active components that can know also be injected into the subcutaneous tissue  of the skin for the purpose of bio stimulation.


Bioactive peptides may be used around the eye area, face, neck and the decolletage. Peptides play a role in  anti-ageing due to their ability to synthesise extra cellular matrix, which is key to preventing skin ageing.


Polynucleotides is a polymer that is composed of several nucleotides that are linked together, DNA and RNA are two types of polynucleotide molecules found in the cell. A chain of polynucleotides has a sugar phosphate backbone with nitrogen bases attached to every sugar molecule. Polynucleotides are also used for biostimulation and cellular rejuvenation.


They are said to promote hydration of the skin and prevent oxidative stress, therefore creating an optimal environment for the growth of new fibroblast cells. As a result they create a production of new collagen and elastin fibres in the dermis of the skin and as a result stimulate cell regeneration.


Polynucleotides are derived from fresh water fish that are intended for human consumption and go through superior levels of purification to ensure product safety. With their use being based on more than 70 years of research.


Exosomes derived from mesenchymal stem cells (MSC’s) extracted from adipose tissue, have been recognised to have a strong ability in cellular regeneration in the skin. MSC cells have been proven to have healing capacities that can be applied in damaged aged skin.


MSC’s have been proven to increase cell proliferation and decrease inflammation in skin lesions. They increase the production of collagen and elastin, inhibit metalloproteinase activation which prevents the breakdown of healthy collagen and elastin and promotes protection from ultra violet radiation induced cellular senescence. Which refers to irreversible damage to a cell’s DNA.


Can biostimulators be combined with other treatments in clinic?


It is suggested to combine aesthetic treatments with biostimulators as it can optimise the results even further. Laser resurfacing, micro-needling or chemical peels can further assist in enhancing the underlying tissues of the epidermis.



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